Nano-Micro Letters

Self-Powered Implantable Skin-Like Glucometer for Real-Time Detection of Blood Glucose Level in vivo

Wanglinhan Zhang1, #, Linlin Zhang1, #, Huiling Gao2, Wenyan Yang1, Shuai Wang1, *, Lili Xing1, Xinyu Xue1, *

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Nano-Micro Lett. (2018) 10: 32

First Online: 16 December 2017 (Article)


*Corresponding author. E-mail: ;




Fig. 1 The potential application, device architecture, material system and experimental design of self-powered implantable skin-like glucometer. a Potential application. b Device architecture, material system and fabrication procedure. c Optical images of the device

Implantable bioelectronics for analyzing physiological biomarkers has recently been recognized as a promising technique in medical treatment or diagnostics. In this study, we developed a self­powered implantable skin-like glucometer for real-time detection of blood glucose level in vivo. Based on the piezo-enzymatic-reaction coupling effect of GOx@ZnO nanowire, the device under an applied deformation can actively output piezoelectric signal containing the glucose-detecting information. No external electricity power source or battery is needed for this device, and the outputting piezoelectric voltage acts as both the biosensing signal and electricity power. A practical application of the skin-like glucometer implanted in mouse body for detecting blood glucose level has been simply demonstrated. These results provide a new technique path for diabetes prophylaxis and treatment.



Diabetes; Biosensor; Electronic-skin; Self-powered; Glucose detection; Implantable electronics

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