19November2018

Nano-Micro Letters

Highly Sensitive MoS2-Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site

Chengbo Liu1,‡, Jingqin Chen1,2, ‡, Ying Zhu1,‡, Xiaojing Gong1, Rongqin Zheng3, Ningbo Chen1, Dong Chen1, Huixiang Yan1, Peng Zhang5, Hairong Zheng4, Zonghai Sheng4,*, Liang Song1,*

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Nano-Micro Lett. (2018) 10: 48

First Online: 08 April 2018 (Article)

DOI:10.1007/s40820-018-0202-8

*Corresponding author. E-mail: zh.sheng@siat.ac.cn ; liang.song@siat.ac.cn

 

Abstract

 


Toc

Photoacoustic technology in combination with molecular imaging is a highly effective method for accurately diagnosing brain glioma. For glioma detection at a deeper site, contrast agents with higher photoacoustic imaging sensitivity are needed. Herein, we report a MoS2–ICG hybrid with indocyanine green (ICG) conjugated to the surface of MoS2 nanosheets. The hybrid significantly enhanced photoacoustic imaging sensitivity compared to MoS2 nanosheets. This conjugation results in remarkably high optical absorbance across a broad near-infrared spectrum, red-shifting of the ICG absorption peak, and photothermal/photoacoustic conversion efficiency enhancement of ICG. A tumor mass of 3.5 mm beneath the mouse scalp was clearly visualized by using MoS2-ICG as a contrast agent for the in vivo photoacoustic imaging of orthotopic glioma, which is nearly two-fold deeper than the tumors imaged in our previous report using MoS2 nanosheet. Thus, combined with its good stability and high biocompatibility, the MoS2–ICG hybrid developed in this study has a great potential for high-efficient tumor molecular imaging in translational medicine.


 

Keywords

MoS2–ICG hybrid; Orthotopic brain glioma; Photoacoustic imaging; Molecular imaging

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