24August2019

Nano-Micro Letters

Crushed Gold Shell Nanoparticles Labeled with Radioactive Iodine as a Theranostic Nanoplatform for Macrophage-Mediated Photothermal Therapy

Sang Bong Lee1, Jae-Eon Lee2, Sung Jin Cho1, 3, Jungwook Chin1, Sang Kyoon Kim7, In-Kyu Lee3, 5, Sang-Woo Lee3, 4, Jaetae Lee4, 6, Yong Hyun Jeon3, 7, *

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Nano-Micro Lett. (2019) 11: 36

First Online: 3 May 2019 (Article)

DOI:10.1007/s40820-019-0266-0

*Corresponding author. E-mail: jeon9014@gmail.com (Yong Hyun Jeon)

 

Abstract

 


Toc

Plasmonic nanostructure-mediated photothermal therapy (PTT) has proven to be a promising approach for cancer treatment, and new approaches for its effective delivery to tumor lesions are currently being developed. This study aimed to assess macrophage-mediated delivery of PTT using radioiodine-124-labeled gold nanoparticles with crushed gold shells (124I-Au@AuCBs) as a theranostic nanoplatform. 124I-Au@AuCBs exhibited effective photothermal conversion effects both in vitro and in vivo and were efficiently taken up by macrophages without cytotoxicity. After the administration of 124I-Au@AuCB-labeled macrophages to colon tumors, intensive signals were observed at tumor lesions, and subsequent in vivo PTT with laser irradiation yielded potent antitumor effects. The results indicate the considerable potential of 124I-Au@AuCBs as novel theranostic nanomaterials and the prominent advantages of macrophage-mediated cellular therapies in treating cancer and other diseases.


 

Keywords

Photothermal therapy; Radionuclide crushed gold shell nanoballs; Macrophage-mediated delivery

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