Nano-Micro Letters

Recent Advances in Tumor Microenvironment Hydrogen Peroxide Responsive Materials for Cancer Photodynamic Therapy

Nan Yang1 , Wanyue Xiao1, Xuejiao Song1, *, Wenjun Wang2, Xiaochen Dong1, 3, *

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Nano-Micro Lett. (2020) 12: 15

First Online: 03 January 2020 (Review)


*Corresponding author. E-mail: (Xiaochen Dong); (Xuejiao Song)





Photodynamic therapy (PDT), as one of non-invasive clinical cancer phototherapy, suffers from the key drawback associated with hypoxia at the tumor microenvironment (TME), which plays an important role in protecting tumor cells from damage caused by common treatments. High concentration of hydrogen peroxide (H2O2), one of the hallmarks of TME, has been recognized as a double-edged sword, posing both challenges, and opportunities for cancer therapy. The promising perspectives, strategies, and approaches for enhanced tumor therapies, including PDT, have been developed based on the fast advances in H2O2-enabled theranostic nanomedicine. In this review, we outline the latest advances in H2O2-responsive materials, including organic and inorganic materials for enhanced PDT. Finally, the challenges and opportunities for further research on H2O2-responsive anticancer agents are envisioned.



Tumor microenvironment; H2O2-responsive; Cancer; Nanomaterials; Photodynamic therapy

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