25February2020

Nano-Micro Letters

Deep-tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window

Xunzhi Wu1, Yongkuan Suo1, Hui Shi1, Ruiqi Liu1, Fengxia Wu1, Tingzhong Wang2, Lina Ma3, Hongguang Liu1, *, Zhen Cheng4, *

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Nano-Micro Lett. (2020) 12: 38

First Online: 24 January 2020 (Article)

DOI:10.1007/s40820-020-0378-6

*Corresponding author. E-mail: simonliu@mail.neu.edu.cn (Hongguang Liu); zcheng@stanford.edu (Zhen Cheng)

 

Abstract

 


Toc

Photothermal therapy (PTT) using near-infrared (NIR) light for tumor treatment has triggered extensive attentions because of its advantages of non-invasion and convenience. Current research on PTT usually uses lasers in the first NIR window (NIR-I; 700-900 nm) as irradiation source. However, the second NIR window (NIR-II; 1000-1700 nm) especially NIR-IIa window (1300-1400 nm) is considered much more promising in diagnosis and treatment as its superiority in penetration depth and maximum permissible exposure (MPE) over NIR-I window. Hereby, we propose the use of laser excitation at 1275 nm, which is approved by Food and Drug Administration (FDA) for physical therapy, as an attractive technique for PTT to balance of tissue-absorption and scattering with water-absorption. Specifically, CuS-PEG nanoparticles with similar absorption values at 1275 and 808 nm, a conventional NIR-I window for PTT, were synthesized as PTT agents and a comparison platform, to explore the potential of 1275 and 808 nm lasers for PTT, especially in deep-tissue settings. The results showed that 1275 nm laser was practicable in PTT. It exhibited much more desirable outcomes in cell ablation in vitro and deep-tissue anti-tumor capabilities in vivo compared to that of 808 nm laser. NIR-IIa laser illumination is superior to NIR-I laser for deep-tissue PTT, and shows high potential to improve the PTT outcome.


 

Keywords

Photothermal therapy; Deep-tissue; NIR-IIa; 1275 nm laser; Molecular imaging

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