Nano-Micro Letters

Near-Infrared Light-Responsive Nitric Oxide Delivery Platform for Enhanced Radioimmunotherapy

Xuanfang Zhou1, Zhouqi Meng1, *, Jialin She1, Yaojia Zhang1, Xuan Yi2, Hailin Zhou2, Jing Zhong2, Ziliang Dong1, Xiao Han1, Muchao Chen1, Qin Fan1, Kai Yang2, Chao Wang1, *

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Nano-Micro Lett. (2020) 12: 100

First Online: 24 April 2020 (Communication)

DOI:10.1007/s40820-020-00431-3

*Corresponding author. E-mail: cwang@suda.edu.cn (Chao Wang), mengzhouqi@gmail.com (Zhouqi Meng)

 

Abstract

 


Toc

Radiotherapy (RT) is a widely used way for cancer treatment. However, the efficiency of RT may come with various challenges such as low specificity, limitation by resistance, high dose and so on. Nitric oxide (NO) is known a very effective radiosensitizer of hypoxic tumor. However, NO cannot circulate in body with high concentration. Herein, an NIR light responsive NO delivery system is developed for controlled and precisely release of NO to hypoxic tumors during radiotherapy. Tert-Butyl nitrite (TBN), which is an efficient NO source, is coupled to Ag2S quantum dots (QDs). NO could be generated and released from the Ag2S QDs effectively under the NIR irradiation due to the thermal effect. In addition, Ag is also a type of heavy metal that can benefit the RT therapy. We demonstrate that Ag2S NO delivery platforms remarkably maximize radiotherapy effects to inhibit tumor growth in CT26 tumor model. Furthermore, immunosuppressive tumor microenvironment is improved by our NO delivery system, significantly enhancing the anti-PD-L1 immune checkpoint blockade therapy. 100% survival rate is achieved by the radio-immune combined therapy strategy based on the Ag2S NO delivery platforms. Our results suggest the promise of Ag2S NO delivery platforms for multi-functional cancer radioimmunotherapy.


 

Keywords

NO delivery; Radio sensitivity; Multifunctional agent; Radioimmunotherapy; Drug delivery

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