Nano-Micro Letters

Self-Assembly Protein Superstructures as a Powerful Chemodynamic Therapy Nanoagent for Glioblastoma Treatment

Tao Zheng1, *, Wentao Wang1, Jon Ashley1, Ming Zhang1, *, Xiaotong Feng1, Jian Shen2, 3, Yi Sun1, *

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Nano-Micro Lett. (2020) 12: 151

First Online: 15 July 2020 (Article)


*Corresponding author. E-mail: taozhe@dtu.dk (Tao Zheng); mzhan@dtu.dk (Ming Zhang); suyi@dtu.dk (Yi Sun)





Glioblastoma (GBM) remains a formidable challenge in oncology. Chemodynamic therapy (CDT) that triggers tumor cell death by reactive oxygen species (ROS) could open up a new door for GBM treatment. Herein, we report a novel CDT nanoagent. Haemoglobin (Hb) and glucose oxidase (GOx) were employed as powerful CDT catalysts. Instead of encapsulating the proteins in drug delivery nanocarriers, we formulate multimeric superstructures as self-delivery entities by crosslinking techniques. Red blood cell (RBC) membranes are camouflaged on the protein superstructures to promote the delivery across blood-brain barrier (BBB). The as-prepared RBC@Hb@GOx nanoparticles (NPs) offer superior biocompatibility, simplified structure and high accumulation at the tumor site. We successfully demonstrate that the NPs could efficiently produce toxic ROS to kill U87MG cancer cells in vitro and inhibit the growth of GBM tumor in vivo, suggesting that the new CDT nanoagent holds great promise for treating GBM. 



Self-assembly protein superstructures; Glioblastoma therapy; Chemodynamic therapy; Self-delivery entities, Blood-brain barrier

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