20November2019

Nano-Micro Letters

Polymer Nanoparticles Prepared by Supercritical Carbon Dioxide for in Vivo Anti-cancer Drug Delivery

 Maofang Hua1, Xiufu Hua2,*

Abstract
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Nano-Micro Letters, , Volume 6, Issue 1, pp 20-23

Publication Date (Web): December 30, 2013 (Article)

DOI:10.5101/nml.v6i1.p20-23

 

Abstract

 


Figure 1 Figure 1 (a) Preparation of drug-loaded nanoparticles by precipitation in SC-CO2; (b) SEM image of BSA-PMMA nanparticles.

A new approach for producing polymer nanoparticles made of bovine serum albumin-poly(methyl methacrylate) conjugate by precipitating in supercritical CO2 is reported. The nanoparticles were loaded with the anti-tumor drug camptothecin. With albumin serving as a nutrient to cells, the drug-encapsulated nanoparticle shows an enhanced ability to kill cancer cells compared to that of the free drug in solution both in vitro and in vivo.


 

Keywords

Protein; Polymer; Nanoparticle; Drug delivery

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