Nano-Micro Letters

Fabrication and Applications of Micro/Nano Structured Devices for Tissue Engineering

Tania Limongi1,*, Luca Tirinato1, Francesca Pagliari2, Andrea Giugni1, Marco Allione1, Gerardo Perozziello3, Patrizio Candeloro3, Enzo Di Fabrizio1

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Nano-Micro Lett.(2017) 9:1

Published online:31 August 2016 (Review)





a Micro and nano structure of central and peripheral nervous systems. b The principal micro- and nanofabrication technologies for TE applications.

Nanotechnology allows the realization of new materials and devices with basic structural unit in the range of 1-100 nm and characterized by gaining control at the atomic, molecular, and supramolecular level. Reducing the dimensions of a material into the nanoscale range usually results in the change of its physiochemical properties such as reactivity, crystallinity, and solubility. This review treats the convergence of last research news at the interface of nanostructured biomaterials and tissue engineering for emerging biomedical technologies such as scaffolding and tissue regeneration. The present review is organized into three main sections. The introduction concerns an overview of the increasing utility of nanostructured materials in the field of tissue engineering. It elucidates how nanotechnology, by working in the submicron length scale, assures the realization of a biocompatible interface that is able to reproduce the physiological cell-matrix interaction. The second, more technical section, concerns the design and fabrication of biocompatible surface characterized by micro and sub-micro scale features, using microfabrication, nanolithography, and miscellaneous nanolithographic techniques. In the last part, we review the ongoing tissue engineering application of nanostructured materials and scaffolds in different fields such as neurology, cardiology, orthopedics and skin tissue regeneration.



Nanomaterials; Nanostructures; Microfabrication; Nanofabrication; Device; Tissue engineering


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